Journal: Materials Today Bio
Article Title: Ultrasound-triggered carrier-free nanoprodrugs activate cGAS-STING pathway to enhance tumor-targeting chemo-immunotherapy
doi: 10.1016/j.mtbio.2026.102858
Figure Lengend Snippet: Evaluation of in vivo tumor growth inhibition by PBSN38-CUR. (A) Schematic illustration of the therapeutic schedule in a 4T1 murine breast cancer model. (B) Tumor volume change curves of the mice following various treatments. The 4T1 tumors harvested after the therapeutic evaluation were photographed and weighed (C and D) . Scale bar: 20 mm. Data were expressed as mean ± standard deviation of biological replicates (n = 5). Tumor-bearing mice were intravenously injected with PBSN38-CUR at an SN38-equivalent dose of 4 mg kg −1 and then treated without or with US irradiation (3 MHz, 1.5 W cm −2 , 50 % duty cycle, 10 min) 4 h after intravenous injection. (E) Representative images of H&E and TUNEL staining in 4T1 tumor sections after different treatments. Scale bar: 100 μm. (F) Characterization of tumoral DC maturation and CD8 + and Foxp3 + T cell infiltration following various treatments. (G) Serum inflammatory cytokine secretion from mice after various treatments. (H) H&E staining of lung tissue collected from mice 15 days after various treatments. (I) Tumor volume change curves of the mice after PBSN38-CUR and anti-PD-L1 antibody combination treatments. The 4T1 tumors harvested at the end of the therapeutic evaluation were photographed and weighed (J and K) . Scale bar: 20 mm. Data were expressed as mean ± standard deviation of biological replicates (n = 5). One-way analysis of variance (ANOVA) followed by the post-Tukey's multiple comparisons test was used to compare multiple groups.
Article Snippet: Picogreen dsDNA quantitation reagent was purchased from Yeasen Biotechnology (Shanghai) Co., Ltd. InVivoMAb anti-mouse PD-L1 (B7-H1) antibody was purchased from Bioxcell.
Techniques: In Vivo, Inhibition, Standard Deviation, Injection, Irradiation, TUNEL Assay, Staining